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The FDA had published the following two guidelines on methanol and EG or DEG, which are also regularly quoted in the warning letters: Testing of Glycerin, Propylene Glycol, Maltitol Solution, Hydrogenated Starch Hydrolysate, Sorbitol Solution, and other High-Risk Drug Components for Diethylene Glycol and Ethylene Glycol Policy for Testing of Alcohol (Ethanol) and Isopropyl Alcohol for Methanol, Including During the Public Health Emergency (COVID-19) Product types In the vast majority of warning letters describing violations of 211.84, inadequate testing of critical components - mainly ethanol and glycerine - plays a role
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