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By promoting self-renewal of mesenchymal stem cells and inhibiting adipogenic differentiation, sulforaphane treatment of adipocytes inhibits breast cancer cell migration and tumor formation 35
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FGF21 also appears to mediate some of the effects of hepatic glucagon and thyroid hormone signaling, since both activation of glucagon receptor (GCGR) (106) and thyroid hormone receptor-β (TR-β) (107) induce secretion of FGF21 by hepatocytes
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