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(e) cross-sectional studies with no time restriction, (f) only studies published in English were included due to resource limitations and to ensure accuracy in data extraction and risk-of-bias assessment
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Conversely, if a patient presents with “pernicious anemia” or severe neurological signs—such as intense tingling in the hands, memory loss, or muscle weakness—the dosage remains the same (usually 1,000 mcg), but the frequency increases significantly
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