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AAV-mediated delivery of the gene encoding VGLUT3, after restoring near normal ABR threshold in 100% of mice, witnessed decline in auditory rescue after 7 weeks ( Gene Silencing Around 20% of genetic SNHL in human are caused by gain-of-function mutations (Yeh et al., 2020), the treatment of which could be accomplished through silencing the expression of mutated allele or through the aforementioned transgene delivery to increase expression of the correct copies of the gene
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