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C domains are most commonly encoded in the same coding DNA sequence (CDS) as their acceptor molecules, upstream of the corresponding A domain and there are only very few examples were a C domain is located in the C terminal proximitiy of the preceding CDS in NRPS 32,33,34

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Whilst palpitations during a calorie deficit are often benign and self-limiting, they should not be dismissed without proper assessment, particularly if they are frequent, prolonged, or accompanied by other symptoms