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128 Likewise, in macrophages, lactylation of K33 on NEDD4, a crucial E3 ubiquitin ligase, reduces the ubiquitination of Caspase-11 by diminishing their binding affinity, leading to Caspase-11-dependent non-canonical pyroptosis
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Animal chronic-dosing studies have not flagged organ toxicity, but animal data do not establish human long-term safety
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