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Disclosure of interest: Daizo Ishii: nothing to disclose, Takeshi Hara: nothing to disclose, Masashi Kuwabara: nothing to disclose, Hiroshi Kondo: nothing to disclose, Shinji Kume: nothing to disclose, Nobutaka Horie: nothing to disclose Poster session I - DIAGNOSIS / ETIOLOGY 04.00 - DIAGNOSIS / ETIOLOGY - 04.01 - DIAGNOSIS/INVESTIGATION OF STROKE ETIOLOGY P356 - ESOC25-1269 ETIOLOGICAL DIFFERENCES IN CLOT CONTRACTION MARKERS: COAGULATION FACTOR XIIIa AND MYOSIN-9 IN ACUTE ISCHEMIC STROKE CLOTS Duaa Jabrah 1 , Abhay Pandit 2 , Ray McCarthy 3 , Michael Gilvarry 3 ,Petra Redfors 4 , Katarina Jood 4 , András Nagy 5 , Sarah Power 6 , Klearchos Psychogios 7 , Georgios Tsivgoulis 8 , Istvan Szikora 5 , Turgut Tatlisumak 4 , Alexandros Rentzos 9 , John Thornton 6 , Karen Doyle *1,2 1 Department of Physiology, University of Galway, Galway, Ireland, 2 CÚRAM–Research Ireland Centre for Research in Medical Devices, University of Galway, Galway, Ireland, 3 Johnson and Johnson Medtech, Neurovascular, Research and Development Department, Galway, Ireland, 4 Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden, 5 Department of Neurointerventions, National Institute of Neurosciences, Budapest, Hungary, 6 Department of Radiology, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland, 7 Stroke Unit, Metropolitan Hospital, Piraeus, Greece, 8 Second Department of Neurology, National & Kapodistrian University of Athens, Athens, Greece, 9 Department of Interventional and Diagnostic Neuroradiology, Sahlgrenska University Hospital, Institute of Clinical Sciences, Department of Radiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden Background and Aims: There is evidence that acute ischemic stroke (AIS) clots may undergo a process of clot contraction, resulting in distinct features such as low porosity and polyhedral erythrocytes