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Disruption of this microbial ecosystem, which is known as gut dysbiosis, is nowadays thought to contribute to the development of many intestinal (IBS, IBD, and colorectal cancer) and extraintestinal (obesity, type 2 diabetes, and CNS-related disorders) disorders [71]
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For quantitation of proliferation and apoptosis, six regions of interest were chosen randomly on the whole slide image using QuPath (v.0.5.1) 66
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