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The 2018 paper that established the compound (PMID 29155147, Biochemical Pharmacology) did the groundwork properly: it tested membrane permeability using parallel artificial membrane and Caco-2 assays, and it tested selectivity against structurally related methyltransferases and against enzymes of the NAD+ salvage pathway, reporting that the methylquinolinium scaffold with a primary amine substitution was both highly permeable and selective — it did not inhibit the related SAM-dependent methyltransferases