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showed that let-7e overexpression induced a reduction in IGFR protein content, suppressed growth arresting the cell cycle in the G1 phase, and increased apoptosis

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Systemic effects less commonly include mild dizziness or lightheadedness (may be copper-related), temporary nausea or headache (typically resolves within hours), mild fatigue (rare, reported with higher doses), and transient flu-like symptoms (very rare, may relate to systemic inflammatory response)