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Vortioxetine vortioxetine is a relatively new antidepressant and there is limited experience when switching, therefore extra caution is required when switching to another antidepressant, doses above 10mg should be reduced to 10mg over a period of 7 days before stopping and starting the new antidepressant when switching from vortioxetine to a MAOI, the manufacturer recommends a 14 day interval [16]