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Subsequently many labs showed that a variety of other agents, able to generate an oxidative stress throughH 2 O 2 generation, increasing concentrations of electrophiles or nitric oxide could also induce GCLC or GCLM subunits or both (Rahman et al., 1996
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5 Conclusions and future priorities The collective evidence positions NGF/TrkA and BDNF/TrkB as context-dependent organizers of osteosarcoma biology and its immune microenvironment
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