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Medications such as methadone to combat opioid addictions are regulated by cytochrome P450 genotypes (e.g., CYP2B6) and can also impact treatment response to addiction
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This finding not only establishes Cu,Zn-SOD activity as an early peripheral biomarker for AD, but crucially demonstrates that copper dyshomeostasis in AD is pharmacologically modifiable and can be monitored via peripheral biomarkers—thereby providing preliminary clinical validation for the translational application of copper chelation therapy
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