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Dr. Siddhi Chavan | Dermatologist | Vitamin B12 deficiency is commonly seen in India especially among the vegetarians Treatment involves taking B12 injections or supplements... | Instagram
Extended NAD+ depletion promotes cell aging by reducing SIRT1 activity, which lowers p63 expression and restricts cell growth
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In a cervical cancer cell line (HeLa), the compound reduced cell proliferation in a concentration- and time-dependent way and lowered expression of phospho-Akt and SIRT1, two proteins tied to tumor progression, while a non-cancer reference cell line was less affected
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