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Discussion This study provides first-in-human evidence that transplantation of human iPSC-NS/PC into the injured human spinal cord is clinically feasible and can be performed with an acceptable safety profile at least in the medium term
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TLR4 is expressed on the ENS, recognizes microbial byproducts such as lipopolysaccharide (LPS), and when activated, initiates a downstream signaling cascade to increase inflammatory cytokine production and immune system activation 247,248
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