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FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation | Communications Biology

ATD - LBD interactions and allosteric coupling The molecular puzzle of how allosteric inhibitors such as Ro25-6981 and ifenprodil promote closure of the ion channel gate despite the binding of agonists to their cognate LBD dimers must be resolved, at least in part, through communication between the ATD and LBD layers and perturbation of the LBD layer from an ‘active’ conformation to an ‘inactive’ state

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