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Activated STING induces robust expression of type I interferons (IFN-α/β) and interferon-stimulated genes via the TBK1–IRF3 axis, forming the characteristic ‘type I interferon signature.’ Persistent type I interferon signaling not only serves as a hallmark of systemic lupus erythematosus but also disrupts immune tolerance, promotes autoantibody production, and enhances pathogenic T cell responses (e.g., Th17), ultimately driving chronic inflammation and tissue injury

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Lycopene from Tomato extract provides powerful UV protection by neutralizing free radicals generated by UV radiation