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Rather than a “rejuvenating” agent, GDF11 may have a detrimental effect on liver senescence. Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy [2021, open-access] : r/longevity
Protein expression and purification Expression and purification of TRF1 TRFH domains was carried out as described previously with some modifications 15,31
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