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According to the Global Burden of Disease 2021 study, IS ranks as the second leading cause of death worldwide and remains a major cause of long-term disability ( Disruption of the blood–brain barrier (BBB) is a key pathological feature of IS, primarily caused by degradation of tight junction (TJ) proteins and increased transcytosis, leading to vascular hyperpermeability ( The BBB is a specialized neurovascular interface that regulates molecular and ionic exchange between the systemic circulation and the central nervous system (CNS), thereby maintaining cerebral homeostasis ( Circadian rhythms are endogenous 24-h cycles regulated by the suprachiasmatic nucleus (SCN) in the hypothalamus, which synchronizes peripheral oscillators across mammalian tissues ( Circadian rhythms influence the onset, progression, and clinical outcomes of IS by regulating diurnal blood pressure patterns, vascular tone, and platelet activity (44)