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Therefore, the translation of nano-delivered collagenase from pre-clinical animal models bearing tumors to clinical trials in cancer patients might be challenged in multiple aspects, such as inadequate enzyme stability in vivo, toxicity to off-target tissues, immune responses to nanocarriers and collagenase, and long-term metastasis risk following ECM degradation
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DS-7300a, a DNA topoisomerase I inhibitor, DXd-based antibody-drug conjugate targeting B7-H3, exerts potent antitumor activities in preclinical models
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