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Experiments showed that VF-13 activated CB1, NPFF1, and NPFF2 receptors, as evidenced by ERK1/2 phosphorylation, inhibition of forskolin-induced cAMP accumulation, and neurite outgrowth in relevant cell lines (CHO, HEK-293, and Neuro 2A)
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But as of September 2026, retatrutide is not FDA-approved for human use and remains under clinical development
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