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Two low-affinity GABA transporters located on the cell membrane were identified by heterologous recombination in yeast, namely, amino acid permease (AAP3) and proline transporter 2 (ProT2) [105,106]

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For the first time, we report that either pharmacologic [ i.e ., N -acetyl-l-cysteine (NAC)] or genetic [ i.e ., glutamate cysteine ligase catalytic subunit (GCLC)/glutamate cysteine ligase modifier subunit (GCLM) overexpression] maneuvers initially triggered a more reducing GSH redox potential or reductive stress, which is followed by pathogenic mitochondrial oxidation at decreased levels of ROS in vitro