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Such findings suggest a sophisticated level of control over ChaC1’s role in cellular responses to stress, particularly in managing intracellular GSH levels ( 3.1.1.2 ATF4 and ATF3 CHAC1, an enzyme that degrades intracellular glutathione, is a direct target of the transcription factor ATF4, activated by UPR signals via the PERK-EIF2A pathway
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Various metal–organic frameworks (MOF) have also been developed
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