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Frontiers | Ferroptosis and bone health: bridging the gap between mechanisms and therapy

The answer is that, although the high-valent metal-oxo heme cores of these intermediates are in fact very similar, the substrate-binding cavities seem to differ substantially in how much access the substrate has to the iron center

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To solve the side effects caused by other drugs on the peripheral spectrum, future drugs that target the CNS will give us more inspiration