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Future directions Future research on radiation induced skin injury (RISI) should concentrate on addressing gap in the current understanding of pathogenesis of the disease, improving clinical assessment tools, exploring innovative management strategies, and optimizing re-irradiation protocols (41)
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CoQ10 supplementation, when added to pregabalin, significantly reduced pain and mitochondrial oxidative stress in FM patients, with improved anxiety and brain activity profiles in a small RCT ( Oxygen-ozone (O₂O₃) therapy, an intervention that activates NRF2, increases SOD, catalase, and HO-1, while suppressing pro-inflammatory cytokines (IL-6, TNF-α, IL-1β) ( − , H₂O₂), protecting mitochondria, and enhancing ATP production ( Molecular hydrogen (H₂) is emerging as a potential therapy targeting oxidative stress, mitochondrial dysfunction, and inflammation
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