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1 Assess whether hospitalization or outpatient monitoring for the first 48 mg dose is appropriate based on comorbidities or other situational factors During outpatient monitoring after the first 48 mg dose, patients should remain in proximity to a healthcare facility that can assess and manage CRS Inform patients of the risk of CRS, and to immediately contact their HCP should signs and symptoms associated with CRS (eg, pyrexia, hypotension, hypoxia, chills, tachycardia, headache, dyspnea) occur at any time EPKINLY should only be administered by a qualified HCP with appropriate medical support to manage severe reactions such as CRS and ICANS Due to the risk of CRS and ICANS, monitor all patients for signs and symptoms Hospitalization may be needed to manage some adverse reactions Administer EPKINLY subcutaneously in 28-day cycles to well-hydrated patients until disease progression or unacceptable toxicity If a dose of EPKINLY is missed or delayed, therapy may need to be restarted

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Each dose delivers essential nutrients including B1 Thiamine 100mg, B6 Pyridoxine Hydrochloride 100mg, B12 Cyanocobalamin, B2 Riboflavin 5mg, B3 Niacinamide 100mg, and B5 D-Panthenol 50mg