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Mechanistically, the oxidative modification of phospholipids in the plasma membrane promotes structural changes that facilitate GSDMD pore formation, which eventually leads to cell swelling and lysis

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et al., for example, the VEGFR inhibitor bevacizumab was added to etoposide and cisplatin and used as a first-line therapy for people with advanced stage small cell lung cancer (SCLC), and this resulted in an increase in the survival rate compared to historical controls who received this chemotherapy regimen without bevacizumab [66]

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