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Animal models used to study the effect of LRRK2 against oxidative stress have shown contradictory results, perhaps suggesting different pathways in LRRK2-mediated neuroprotection
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For example, urolithin A can increase the expression of tryptophan hydroxylase-2 (TPH2) in differentiated rat serotonergic raphe cells via an increase in the transcriptional activity of 1,25-dihydroxyvitamin D 3 (73), the active form of vitamin D
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