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The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI - PMC
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On the other hand, the combination of astragalus polysaccharide (APS) and TIL improved the expression of the Nrf2 pathway, suggesting that the crosstalk between Nrf2 and NF-κB could be a new therapeutic target against hepatotoxicity (Farag et al., 2019)
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