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302 ECM-degrading enzymes regulate VEGF signaling through: releasing bio-unavailable ligands: due to the varying heparin-binding and heparan sulfate-binding capacities of VEGF isoforms, some VEGF ligands are sequestered in the ECM

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Combination therapies are also employed to improve efficacy and mitigate adverse effects, for example, combining methotrexate with a biologic to reduce immunogenicity or combining phototherapy with topical treatments to achieve greater plaque clearance (Arora et al