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While moderate caffeine intake (about 400 mg, or four cups of brewed coffee, daily) may actually support healthy bone metabolism, excess caffeine (≥800 mg daily) appears to interfere with osteoblast and osteoclast function
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Rowell JP, Simpson KL, Stott K, Watson M and Thomas JO (2012) HMGB1‐facilitated p53 DNA binding occurs via HMG‐Box/p53 transactivation domain interaction, regulated by the acidic tail
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