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2 Macrophages, serving as central orchestrators of antimycobacterial immunity, 3 not only serve as the first line of defense against Mtb infection but also deploy a broad antibacterial arsenal—LC3-mediated phagocytosis, metabolic reprogramming, antimicrobial metabolites and peptides, inflammatory factors, and stress granules—while integrating upstream IFN-γ/JAK/STAT1, inflammasome and mTOR signals that drive M1/M2 plasticity and regulate the process of antigen presentation
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