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For instance, M9S1 extracted from Moringa oleifera significantly downregulated the expression of ZIP6 in MDA-MB-231 tumor, 602 treatment with STAT3 inhibitor peptide, cell-permeable (#573096, Sigma)
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Mechanistically, the DNA-binding region of E2F1 interacts with the transcription-activation domain of FOXO3 and thereby attenuates its transcriptional activity 92
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