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Triggers, including spicy food (capsaicin), heat, ultraviolet light, physical or chemical stimuli, and microbes, induce the release of various mediators from multiple cells, such as keratinocytes (for instance, cathelicidin, chemokines, and vascular endothelial growth factor), endothelial cells (nitric oxide and adhesion molecules), macrophages (inflammatory factors, matrix metalloproteinases, and nitric oxide), mast cells (matrix metalloproteinases and histamines), and T helper cells (interferons, tumor necrosis factor, and interleukins)
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