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The addition of glucagon receptor activation introduces direct thermogenic and lipolytic effects that neither GLP-1 nor GIP agonism provides alone, creating a mechanism that, in some ways, bridges the gap between the direct fat-targeting approach of AOD 9604 and the systemic metabolic reprogramming of tirzepatide
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Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabetes
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