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GPX4-ablation in mice and cells revealed downstream 12/15-lipoxygenase-derived lipid peroxidation, trigger apoptosis-inducing factor-mediated cell death, and subsequent oxidative stress (Seiler et al., During ferroptosis, cytosolic ferritin may undergo lysosomal breakdown (ferritinophagy) to further contribute to LIP—ferritinophagy appears to augment cysteine deficiency-induced ferroptosis (Gao et al., via hyperpolarized mitochondrial membrane potential (Gao et al., 2007
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[DOI] [PMC free article] [PubMed] [Google Scholar] 78.Palanca A., Ampudia-Blasco F.J., Real J.T
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