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Mechanistically, vitexin enhanced the nuclear translocation of NRF2 and increased HO-1 mRNA expression by binding to KEAP1, thereby activating the KEAP1/NRF2/HO-1 signaling pathway (Song et al., 2023)
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The drugs can be classified as follows: (1) Drugs directly or indirectly inhibiting system x c- (e.g., erastin, sorafenib, and sulfasalazine)
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