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At the same time, it has also been shown that GPX2 alleviates the apoptosis response of MCF7 cells to oxidative stress (Yan and Chen, 2006).Therefore, GPX2 is believed to have the effect of oxidative stress and reducing the inflammatory response.The inhibitory effect of GPX2 on oxidative stress is a key link in inhibiting tumor development.Therefore, the antioxidant function of GPX2 may provide an early defense against the development of colon cancer.In studies on human colon cancer cells, GPX2 prevents inflammatory factor-driven carcinogenic processes by inhibiting the expression of COX-2 and mPGES-1 in human colon cancer cells and reducing inappropriate responses to inflammatory stimuli (Banning et al., 2008a).The anti-inflammatory effect of GPX2 is confirmed in a study of the induction of inflammation-associated colon cancer in WT and GPX2 KO mice under AOM/DSS combined with different selenium content (Brigelius-Flohé and Kipp, 2012).The inflammatory response of GPX2 KO mice was generally heavier, especially in the moderate selenium deficiency group.In adequate selenium content, inflammation and tumor cell production are reduced (Brigelius-Flohé and Kipp, 2012).However, it is interesting to note that the tumor volume in GPX2 KO mice is smaller compared to WT mice, which proves that GPX2 supports the growth of tumor cells, which has been confirmed in studies in which GPX2 inhibits the metastasis and invasion of HT-29 adenocarcinoma cells (Banning et al., 2008b).This may be related to the anti-apoptosis effect of GPX2, and inhibition of apoptosis may also explain why tumors in WT cells grow better than those in GPX2 KO cells (Brigelius-Flohé and Kipp, 2012).In conclusion, GPX2 is a protective enzyme with oxidative stress and reduces inflammatory response, and its prominent role in inflammation seems to be prevention.Thus, GPX2 can stop tumorigenesis but support the growth of tumors that have already occurred.Therefore, the gain or loss of increased GPX2 expression mainly depends on the current state of the tumor and the stage of the tumor

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10.1007/s13238-020-00694-x 296 WangY.BaiC.RuanY.LiuM.ChuQ.QiuL.et al