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In the oxidized state with two nearby cysteines forming a disulfide bond and the third cysteine unmodified, HMGB1 acts as a proinflammatory cytokine (Yang et al., 2021) which can interact with TLR4 (Pauletti et al., 2019)
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Longitudinal analyses will be essential to determine whether these markers can reliably predict PCC onset or persistence
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