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The controlled studies in humans have focused almost exclusively on skin health and aesthetics, and to a lesser extent on wound healing and hair growth

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Enhanced sampling: Implemented late Initially limited to one supplier Not justified with defined protocols, sample size rationale, or tightened acceptance criteria Re-inspection of finished product: Proposed but not supported by documented procedures or defined AQL controls FDA treated these issues collectively as a failure to prevent microbiological and particulate contamination , not as isolated supplier or inspection gaps