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However, an issue was the observation that mPGES-2 activity was partially independent from glutathione and that DTT induced a 4-fold better efficiency of the proteins (Tanikawa et al., 2002)
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Both reports confirm the expert opinion recently reported by the author where lactate (Warburg effect) increases the steady-state ROS condition in cancer cells 4 and the published work that antioxidants are the guardians and gatekeepers against oxidative stress-induced hepatocarcinogenesis 24
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