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Retatrutide reconstitution (common setup) Vial Size 10 mg BAC Water 2 mL Concentration 5 mg/mL 2 mg 40 U 4 mg 80 U 6 mg 120 U* 9 mg 180 U* 12 mg 240 U* Vial Size 10 mg BAC Water 1 mL Concentration 10 mg/mL 2 mg 20 U 4 mg 40 U 6 mg 60 U 9 mg 90 U 12 mg 120 U* *Volumes over 100 U (1 mL on a U-100 insulin syringe) need a larger syringe or a split injection

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Note: Peak area percentages reflect relative detector response, not necessarily equal mg-for-mg concentration across peptides of different size and structure