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NCOA4 showed no significant change in the WM of AD patients independent of disease severity, while a gradual decrease of NCOA4 expression during the progression of the pathology was observed

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Cofactor for L-methylmalonyl-coenzyme A mutase 5-Deoxyadenosylcobalamin is required by the enzyme that catalyzes the conversion of L-methylmalonyl-coenzyme A to succinyl-coenzyme A (succinyl-CoA), which then enters the citric acid cycle ( Figure 2 )