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In addition, multiple studies have shown the integrity of the ECM and islet microenvironment is connected to the T1D pathogenesis by promoting β cell survival and blocking T cell infiltration into islet tissue (43)
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313 Moreover, in esophageal squamous cell carcinoma, reduced expression of CLDN 1, 4, and 7 was identified, which might be candidate prognostic biomarkers for esophageal cancer
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