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Scenario 3 (New Problem and Injection Same Day): A patient presents for shoulder pain evaluation, and the physician diagnoses rotator cuff syndrome (M75.11) and performs an intraarticular injection

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Metabolic Perturbation# While increased NAD+ is generally considered beneficial, the broader metabolic consequences of NNMT inhibition -- including effects on polyamine metabolism, one-carbon metabolism, and other SAM-dependent pathways -- have not been systematically evaluated