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Rats treated with 1.0 mg/kg dihexa located the hidden platform 35–50% faster than vehicle-treated controls by day 5 of testing, and probe trial data (platform removed, time spent in target quadrant measured) demonstrated significantly stronger spatial memory retention

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Emerging evidence suggests that oxidative stress can enhance allergen penetration, promote epithelial damage, and perpetuate inflammatory cycles in EoE and other atopic diseases ( GPX3 was downregulated in esophageal biopsies from EoE patients ( Methods Since EoE can affect all ages, we analyzed 36 pediatric (1−18 years) and 39 adult (≥18 years) samples collected at Lurie Children's Hospital ( EoE was diagnosed according to 2011 consensus guidelines, which were standard of care at the time of sample collection ( For the pediatric cohort, sample exclusion criteria included non-esophageal eosinophilic gastrointestinal disease (EGID), other inflammatory disease, infection, and chromosomal or anatomical abnormalities ( Endoscopic features of EoE were graded by the endoscopist per the Eosinophilic Esophagitis Endoscopic Reference Score (EREFS) system ( 2 HPF, and basal zone hyperplasia was classified as none (0), mild (1), mild-moderate (2), moderate (3), moderate-severe (4), or severe (5) in the pediatric cohort

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