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The translocation of Nrf-2 to the nucleus caused by OS has been shown to activate the glutamate cysteine ligase modifier subunit, glutathione S-transferase π, GSH availability and use, glutathione reductase, and glutathione peroxidase (Sporn and Liby, 2012
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O-GlcNAc synthesis leads to the activation of many transcriptional factors, for instance, Sp1, phosphorylation of Eukaryotic Initiation Factor 2 (eIF2), and sirtuin-1 (SIRT1) [156]
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