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In addition to NF-ฮบB suppression, metformin exerts immunomodulatory effects by influencing macrophage polarization, doing so by promoting a shift from the proinflammatory M1 phenotype toward the anti-inflammatory M2 phenotype, which is associated with tissue repair and the resolution of inflammation (Figure 5) [162]
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Firstly, LA (4 g) and NaOH (0.7755 g) were dispersed uniformly in deionized water (10 mL) to prepare the ST solution
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