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The release of Aβ peptides is strongly dependent on the amyloidogenic APP processing pathway, initiated by BACE1-mediated β-secretase cleavage of APP generating the amino-terminus (N-terminus) of Aβ peptides [6,7,8] (Figure 1)
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As healthcare professionals continue to manage patients with musculoskeletal and inflammatory conditions, treatment decisions should consider both symptom control and gastrointestinal risk, particularly in appropriate patients receiving NSAID therapy
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