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Mice given myostatin-blocking antibodies gained 20% to 30% or more muscle mass, but humans given bimagrumab gained only 4% to 8% (61:11)
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Bedaquiline does not induce or inhibit major CYP isoenzymes, namely, CYP1A2, CYP2C9, CYP2C19, or CYP2D6 at clinically relevant concentrations, minimizing the risk of CYP450-related interactions (Mesens et al., 2010)
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